# CEP43

Source: https://onco.cc/targets/cep43/  
OnCo record `cep43` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.

## Summary

Required for anchoring microtubules to the centrosomes. Required for ciliation.

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.23, genetic association 0.52, somatic mutation 0.49, animal model 0.40).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: centrosomal protein 43; Centrosomal protein 43; FGFR1OP
- Tags: cancer-genes-wave
- Symbol: CEP43
- Class: other
- Biology: Required for anchoring microtubules to the centrosomes. Required for ciliation. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 6q27 (HGNC).
- Where found: Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17012: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17012
- UniProt O95684: https://www.uniprot.org/uniprotkb/O95684/entry
- NCBI Gene 11116: https://www.ncbi.nlm.nih.gov/gene/11116
- Ensembl ENSG00000213066: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213066

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/cep43.json