# CEP89

Source: https://onco.cc/targets/cep89/  
OnCo record `cep89` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.

## Summary

Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: centrosomal protein 89; Centrosomal protein of 89 kDa; FLJ14640; CCDC123
- Tags: cancer-genes-wave
- Symbol: CEP89
- Class: oncogene
- Biology: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 19q13.11 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25907: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25907
- UniProt Q96ST8: https://www.uniprot.org/uniprotkb/Q96ST8/entry
- NCBI Gene 84902: https://www.ncbi.nlm.nih.gov/gene/84902
- Ensembl ENSG00000121289: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121289

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/cep89.json