# CFLAR

Source: https://onco.cc/targets/cflar/  
OnCo record `cflar` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.

## Summary

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Bicalutamide.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CASP8 and FADD like apoptosis regulator; CASP8 and FADD-like apoptosis regulator; Casper; CLARP; FLAME; I-FLICE; c-FLIP; cFLIP; CASP8AP1
- Tags: cancer-genes-wave
- Symbol: CFLAR
- Class: other
- Biology: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Locus 2q33.1 (HGNC).
- Where found: Prostate cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1876: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1876
- UniProt O15519: https://www.uniprot.org/uniprotkb/O15519/entry
- NCBI Gene 8837: https://www.ncbi.nlm.nih.gov/gene/8837
- Ensembl ENSG00000003402: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000003402

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/cflar.json