# CHCHD7

Source: https://onco.cc/targets/chchd7/  
OnCo record `chchd7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.

## Summary

UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7".

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.09, somatic mutation 0.89).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: coiled-coil-helix-coiled-coil-helix domain containing 7; Coiled-coil-helix-coiled-coil-helix domain-containing protein 7; MGC2217; COX23
- Tags: cancer-genes-wave
- Symbol: CHCHD7
- Class: other
- Biology: UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7". Location: Mitochondrion intermembrane space (UniProt). Locus 8q12.1 (HGNC).
- Where found: Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28314: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28314
- UniProt Q9BUK0: https://www.uniprot.org/uniprotkb/Q9BUK0/entry
- NCBI Gene 79145: https://www.ncbi.nlm.nih.gov/gene/79145
- Ensembl ENSG00000170791: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170791

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/)

---
JSON: https://onco.cc/api/v1/entities/chchd7.json