# CHD4

Source: https://onco.cc/targets/chd4/  
OnCo record `chd4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CHD4 (ATP-dependent chromatin remodeler CHD4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer, Colorectal cancer, Renal cell carcinoma and 5 more.

## Summary

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localises to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination.

Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.28, genetic association 0.00, somatic mutation 0.95). IntOGen calls it a driver in 9 cohorts (6 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Renal Clear Cell Carcinoma, Colon Adenocarcinoma, Head and Neck Squamous Cell Carcinoma, Neuroblastoma, Endometrial Carcinoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: chromodomain helicase DNA binding protein 4; ATP-dependent chromatin remodeler CHD4; Mi-2b; Mi2-BETA
- Tags: cancer-genes-wave
- Symbol: CHD4
- Class: transcription
- Biology: ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localises to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 12p13.31 (HGNC).
- Where found: Endometrial cancer: Open Targets association 0.55 with endometrial cancer (MONDO_0011962); IntOGen driver in 3 cohorts (UCEC); Colorectal cancer: Open Targets association 0.57 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COAD); Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC); Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1919: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1919
- UniProt Q14839: https://www.uniprot.org/uniprotkb/Q14839/entry
- NCBI Gene 1108: https://www.ncbi.nlm.nih.gov/gene/1108
- Ensembl ENSG00000111642: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111642

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/chd4.json