# CHD7

Source: https://onco.cc/targets/chd7/  
OnCo record `chd7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.

## Summary

ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: chromodomain helicase DNA binding protein 7; ATP-dependent chromatin remodeler CHD7; KIAA1416; FLJ20357; FLJ20361
- Tags: cancer-genes-wave
- Symbol: CHD7
- Class: tumor-suppressor
- Biology: ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 8q12.2 (HGNC).
- Where found: Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20626: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20626
- UniProt Q9P2D1: https://www.uniprot.org/uniprotkb/Q9P2D1/entry
- NCBI Gene 55636: https://www.ncbi.nlm.nih.gov/gene/55636
- Ensembl ENSG00000171316: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171316

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

---
JSON: https://onco.cc/api/v1/entities/chd7.json