# Christine E. Brown

Source: https://onco.cc/people/christine-brown/  
OnCo record `christine-brown` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Engineered the IL13Rα2 CAR-T cells that produced a complete response in glioblastoma when infused into the brain.

## Summary

Christine Brown is Deputy Director of the T Cell Therapeutics Research Laboratories at City of Hope. An immunologist leading CAR-T development for brain tumours, she engineered the IL13Rα2 CAR-T cells that produced a complete response in glioblastoma when infused into the brain. Her papers include the 2016 New England Journal of Medicine case of regression of glioblastoma after intraventricular CAR T-cell therapy and a Nature Medicine phase 1 trial of locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma. Her work established locoregional delivery and continues on armoured and next-generation CAR designs for glioma and glioblastoma.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Deputy Director, T Cell Therapeutics Research Laboratories, City of Hope
- Specialisms: CAR-T cell therapy; Glioblastoma; Regional delivery

## Sources

- City of Hope research faculty: https://www.cityofhope.org/research/find-a-researcher
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Brown%20CE%5BAuthor%5D
- Google Scholar: https://scholar.google.com/scholar?q=Christine%20E.%20Brown

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- technologies: [Armoured, logic-gated & next-gen CARs](https://onco.cc/technologies/armored-car/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- institutions: [City of Hope](https://onco.cc/institutions/city-of-hope/)

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