# Cervical precancer (CIN, HSIL/LSIL)

Source: https://onco.cc/terms/cin-hsil/  
OnCo record `cin-hsil` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Abnormal cervical cells caused by HPV that can turn into cancer over 10-20 years. Screening finds them; a five-minute procedure removes them.

## Summary

Cervical intraepithelial neoplasia grades 1-3, now reported as low-grade (LSIL, CIN1) or high-grade (HSIL, CIN2-3) squamous intraepithelial lesions; adenocarcinoma in situ is the glandular equivalent. Most LSIL regresses; ~30% of untreated CIN3 progresses to cancer within 30 years. Treated by LEEP/LLETZ excision, cold-knife cone, cryotherapy, or thermal ablation. HPV16 is the most persistent and carcinogenic type.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Cervical_intraepithelial_neoplasia
- Wikipedia: https://en.wikipedia.org/wiki/Cervical_intraepithelial_neoplasia

## Connected records

- cancers: [Anal high-grade squamous intraepithelial lesions (precursor)](https://onco.cc/cancers/anal-hsil-precursor/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Vaginal cancer](https://onco.cc/cancers/vaginal/), [Vaginal squamous cell carcinoma (HPV-associated)](https://onco.cc/cancers/vaginal-squamous-cell-carcinoma/)
- technologies: [Colposcopy and excisional treatment (LEEP/LLETZ, cone)](https://onco.cc/technologies/colposcopy-excision/), [HPV DNA testing and self-sampling](https://onco.cc/technologies/hpv-testing/), [Thermal ablation and cryotherapy for cervical precancer](https://onco.cc/technologies/precancer-ablation/), [Visual inspection with acetic acid (VIA) for cervical screening](https://onco.cc/technologies/via-cervical-screening/)
- people: [Harald zur Hausen](https://onco.cc/people/harald-zur-hausen/), [Jade Goody](https://onco.cc/people/jade-goody/)
- bottlenecks: [Prevention we already have is not deployed](https://onco.cc/bottlenecks/b-prevention-adoption/)
- pathways: [Basement membrane & tissue barriers](https://onco.cc/pathways/basement-membrane-tissue-barriers/), [Field cancerisation](https://onco.cc/pathways/field-cancerisation/), [Oncogenic viruses](https://onco.cc/pathways/oncogenic-viruses/)

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JSON: https://onco.cc/api/v1/entities/cin-hsil.json