# Cirrhosis

Source: https://onco.cc/terms/cirrhosis/  
OnCo record `cirrhosis` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Permanent scarring of the liver after years of damage from hepatitis B or C, alcohol or fatty liver disease. It is the soil in which most liver cancers grow, and its severity limits which cancer treatments a patient can withstand.

## Summary

Around 80-90% of hepatocellular carcinomas arise in cirrhotic livers, at roughly 2-4% per year, which is why patients with cirrhosis are offered six-monthly ultrasound and AFP surveillance. Hepatitis B vaccination and antiviral therapy, hepatitis C cure with direct-acting antivirals and, prospectively, GLP-1 agonists for metabolic liver disease are the main preventive levers. Cirrhosis also complicates treatment: it causes portal hypertension, low platelets and impaired drug clearance, and is graded by Child-Pugh and ALBI for treatment eligibility.

## Fields

- Kind: Term
- Last checked: 2026-09-09
- Also known as: cirrhotic; liver cirrhosis; liver fibrosis; MASLD; MASH; NASH; NAFLD; fatty liver; chronic hepatitis B; hepatitis B; hepatitis C

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Cirrhosis
- Wikipedia: https://en.wikipedia.org/wiki/Cirrhosis

## Connected records

- terms: [BCLC staging](https://onco.cc/terms/bclc-staging/), [Child-Pugh score](https://onco.cc/terms/child-pugh/), [Hepatotoxicity (liver enzyme elevation)](https://onco.cc/terms/hepatotoxicity/), [LI-RADS (Liver Imaging Reporting and Data System)](https://onco.cc/terms/li-rads/), [Mechanical theory: stiffness, pressure and force as causes](https://onco.cc/terms/mechanical-theory-of-cancer/), [Portal vein tumour thrombus (macrovascular invasion)](https://onco.cc/terms/portal-vein-tumour-thrombus/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)
- fronts: [Prevention & Risk](https://onco.cc/fronts/prevention/)

---
JSON: https://onco.cc/api/v1/entities/cirrhosis.json