# CLCN6

Source: https://onco.cc/targets/clcn6/  
OnCo record `clcn6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.16, affected pathway 0.89, genetic association 0.05).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Cl-/H+ antiporter 6; H(+)/Cl(-) exchange transporter 6; CLC-6; KIAA0046; ClC-6
- Tags: cancer-genes-wave
- Symbol: CLCN6
- Class: other
- Biology: Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Location: Late endosome membrane (UniProt). Locus 1p36.22 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2024: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2024
- UniProt P51797: https://www.uniprot.org/uniprotkb/P51797/entry
- NCBI Gene 1185: https://www.ncbi.nlm.nih.gov/gene/1185
- Ensembl ENSG00000011021: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000011021

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/clcn6.json