# CLIP1

Source: https://onco.cc/targets/clip1/  
OnCo record `clip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.

## Summary

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Cervical Squamous Cell Carcinoma, Oesophageal Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CAP-Gly domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CYLN1; CLIP170; CLIP-170
- Tags: cancer-genes-wave
- Symbol: CLIP1
- Class: tumor-suppressor
- Biology: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle (UniProt). Locus 12q24.31 (HGNC).
- Where found: Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903); Cervical cancer: IntOGen driver in 1 cohort (CESC); Oesophageal cancer: IntOGen driver in 1 cohort (ESCC); Non-small-cell lung cancer: Open Targets association 0.59 with non-small cell lung carcinoma (MONDO_0005233); Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10461: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10461
- UniProt P30622: https://www.uniprot.org/uniprotkb/P30622/entry
- NCBI Gene 6249: https://www.ncbi.nlm.nih.gov/gene/6249
- Ensembl ENSG00000130779: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130779

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Cervical cancer](https://onco.cc/cancers/cervical/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Oesophageal squamous cell carcinoma](https://onco.cc/cancers/oesophageal-squamous-cell-carcinoma/)

---
JSON: https://onco.cc/api/v1/entities/clip1.json