# CLSP-5282

Source: https://onco.cc/drugs/clsp-5282/  
OnCo record `clsp-5282` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CLSP-5282 is an experimental T cell engager from Clasp Therapeutics, in phase 1 trials for KRAS G12V-mutant solid tumours in HLA-A*03:01-positive patients.

## Summary

CLSP-5282 is a T cell engager from Clasp Therapeutics. A T cell engager designed to redirect T cells to tumours presenting the KRAS G12V peptide on HLA-A*03:01; the lead of the company's KRAS T cell engager portfolio. Its furthest stage is phase 1, for KRAS G12V-mutant solid tumours in HLA-A*03:01-positive patients (registry lists non-small cell lung, pancreatic and colorectal cancer). ClinicalTrials.gov registers it in one study linked below. SENTINEL-101 phase 1 NCT07650357 registered, NOT YET RECRUITING. The April 2026 release said the IND was expected in 2026. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: CLSP-5282
- Modality: T cell engager
- Mechanism: A T cell engager designed to redirect T cells to tumours presenting the KRAS G12V peptide on HLA-A*03:01; the lead of the company's KRAS T cell engager portfolio.

## Sources

- Clasp Therapeutics: clasptx.com: https://www.clasptx.com/press-release-publications/clasp-therapeutics-unveils-first-in-class-kras-t-cell-engager-clsp-5282-at-aacr-2026
- Clasp Therapeutics: clinicaltrials.gov: https://clinicaltrials.gov/study/NCT07650357
- ClinicalTrials.gov: trials of CLSP-5282: https://clinicaltrials.gov/search?intr=CLSP-5282

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- targets: [KRAS](https://onco.cc/targets/kras/)
- companies: [Clasp Therapeutics](https://onco.cc/companies/clasp-therapeutics/)
- trials: [A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)](https://onco.cc/trials/nct07650357/)

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JSON: https://onco.cc/api/v1/entities/clsp-5282.json