# CLTC

Source: https://onco.cc/targets/cltc/  
OnCo record `cltc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CLTC (Clathrin heavy chain 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Renal cell carcinoma, Hepatocellular carcinoma and 5 more.

## Summary

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilisation of kinetochore fibres of the mitotic spindle by acting as inter-microtubule bridge.

Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.94, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 5 cohorts (3 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Upper Tract Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: clathrin heavy chain; Clathrin heavy chain 1; Hc; CLTCL2
- Tags: cancer-genes-wave
- Symbol: CLTC
- Class: oncogene
- Biology: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilisation of kinetochore fibres of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fibre tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilisation of the lattice promoting uncoating. Location: Cytoplasmic vesicle membrane; Membrane, coated pit; Melanosome; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 17q23.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA); Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC); Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2092: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2092
- UniProt Q00610: https://www.uniprot.org/uniprotkb/Q00610/entry
- NCBI Gene 1213: https://www.ncbi.nlm.nih.gov/gene/1213
- Ensembl ENSG00000141367: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141367

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/cltc.json