# CMTR2

Source: https://onco.cc/targets/cmtr2/  
OnCo record `cmtr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CMTR2 (Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognises a guanosine cap on RNA independently of its N(7) methylation status.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cap methyltransferase 2; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; FLJ11171; MTr2; FTSJD1
- Tags: cancer-genes-wave
- Symbol: CMTR2
- Class: tumor-suppressor
- Biology: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognises a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. Location: Nucleus; Cytoplasm (UniProt). Locus 16q22.2 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25635: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25635
- UniProt Q8IYT2: https://www.uniprot.org/uniprotkb/Q8IYT2/entry
- NCBI Gene 55783: https://www.ncbi.nlm.nih.gov/gene/55783
- Ensembl ENSG00000180917: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180917

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/cmtr2.json