# CNBP

Source: https://onco.cc/targets/cnbp/  
OnCo record `cnbp` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.88, animal model 0.50, genetic association 0.00, somatic mutation 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CCHC-type zinc finger nucleic acid binding protein; RNF163; ZCCHC22; CNBP1; DM2; ZNF9
- Tags: cancer-genes-wave
- Symbol: CNBP
- Class: transcription
- Biology: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Binds to RNA. Location: Nucleus; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 3q21.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13164: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13164
- UniProt P62633: https://www.uniprot.org/uniprotkb/P62633/entry
- NCBI Gene 7555: https://www.ncbi.nlm.nih.gov/gene/7555
- Ensembl ENSG00000169714: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169714

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cnbp.json