# CNKSR2

Source: https://onco.cc/targets/cnksr2/  
OnCo record `cnksr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

May function as an adapter protein or regulator of Ras signalling pathways.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: connector enhancer of kinase suppressor of Ras 2; Connector enhancer of kinase suppressor of ras 2; KIAA0902; CNK2; KSR2
- Tags: cancer-genes-wave
- Symbol: CNKSR2
- Class: other
- Biology: May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus Xp22.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19701: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19701
- UniProt Q8WXI2: https://www.uniprot.org/uniprotkb/Q8WXI2/entry
- NCBI Gene 22866: https://www.ncbi.nlm.nih.gov/gene/22866
- Ensembl ENSG00000149970: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149970

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/cnksr2.json