# CNOT9

Source: https://onco.cc/targets/cnot9/  
OnCo record `cnot9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CNOT9 (CCR4-NOT transcription complex subunit 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.

## Summary

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription.

IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Cutaneous Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CCR4-NOT transcription complex subunit 9; RCD1; RCD1+; CT129; CAF40; RQCD1
- Tags: cancer-genes-wave
- Symbol: CNOT9
- Class: oncogene
- Biology: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Location: Nucleus; Cytoplasm, P-body (UniProt). Locus 2q35 (HGNC).
- Where found: Melanoma: IntOGen driver in 2 cohorts (MEL, SKCM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10445: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10445
- UniProt Q92600: https://www.uniprot.org/uniprotkb/Q92600/entry
- NCBI Gene 9125: https://www.ncbi.nlm.nih.gov/gene/9125
- Ensembl ENSG00000144580: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144580

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

---
JSON: https://onco.cc/api/v1/entities/cnot9.json