# COL1A1

Source: https://onco.cc/targets/col1a1/  
OnCo record `col1a1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

COL1A1 (Collagen alpha-1(I) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Anal cancer, Pancreatic ductal adenocarcinoma and 3 more.

## Summary

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, animal model 0.57, genetic association 0.00, somatic mutation 0.79). IntOGen calls it a driver in 5 cohorts (2 activating, 3 loss-of-function), covering Anal Squamous Cell Carcinoma, Glioblastoma Multiforme, Melanoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: collagen type I alpha 1 chain; Collagen alpha-1(I) chain; OI4
- Tags: cancer-genes-wave
- Symbol: COL1A1
- Class: tumor-suppressor
- Biology: Type I collagen is a member of group I collagen (fibrillar forming collagen). Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 17q21.33 (HGNC).
- Where found: Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089); Anal cancer: IntOGen driver in 1 cohort (ANSC); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Multiple myeloma: IntOGen driver in 1 cohort (PCM); Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM); Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2197: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2197
- UniProt P02452: https://www.uniprot.org/uniprotkb/P02452/entry
- NCBI Gene 1277: https://www.ncbi.nlm.nih.gov/gene/1277
- Ensembl ENSG00000108821: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108821

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Anal cancer (squamous cell carcinoma)](https://onco.cc/cancers/anal/), [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Melanoma](https://onco.cc/cancers/melanoma/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

---
JSON: https://onco.cc/api/v1/entities/col1a1.json