# COL6A3

Source: https://onco.cc/targets/col6a3/  
OnCo record `col6a3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

COL6A3 (Collagen alpha-3(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Melanoma.

## Summary

Collagen VI acts as a cell-binding protein.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma. In OnCo, 1 product record names it (Vimseltinib).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: collagen type VI alpha 3 chain; Collagen alpha-3(VI) chain
- Tags: cancer-genes-wave
- Symbol: COL6A3
- Class: tumor-suppressor
- Biology: Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 2q37.3 (HGNC).
- Where found: Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2213: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2213
- UniProt P12111: https://www.uniprot.org/uniprotkb/P12111/entry
- NCBI Gene 1293: https://www.ncbi.nlm.nih.gov/gene/1293
- Ensembl ENSG00000163359: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163359

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)
- drugs: [Vimseltinib](https://onco.cc/drugs/vimseltinib/)

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JSON: https://onco.cc/api/v1/entities/col6a3.json