# A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)

Source: https://onco.cc/trials/companion-002/  
OnCo record `companion-002` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial testing Tovecimig in biliary tract cancer and bladder & urothelial cancer, active and no longer recruiting.

## Summary

A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) is a phase 2/3 interventional study registered as NCT05506943, led by Compass Therapeutics, and active but no longer recruiting on the registry. Official title: A Phase 2/3 Randomised, Controlled Study of CTX-009 in Combination With Paclitaxel Versus Paclitaxel Alone in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers Who Have Received One Prior Systemic Chemotherapy Regimen. Planned enrolment is 168 participants (actual). The study started in 2023-01-09 and primary completion is expected in 2027-08-31. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-11
- Also known as: COMPANION-002
- Tags: ctgov-ingest
- Registry id: NCT05506943
- Phase: 2/3
- Setting: A Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination With Paclitaxel Versus Paclitaxel Alone in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers Who Have Received One Prior Systemic Chemotherapy Regimen
- Sponsor: Compass Therapeutics
- Enrolled: 168

## Sources

- ClinicalTrials.gov NCT05506943: https://clinicaltrials.gov/study/NCT05506943

## Connected records

- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/)
- drugs: [Tovecimig](https://onco.cc/drugs/tovecimig/)
- companies: [Compass Therapeutics](https://onco.cc/companies/compass-therapeutics/)

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JSON: https://onco.cc/api/v1/entities/companion-002.json