# Costas A. Lyssiotis

Source: https://onco.cc/people/costas-lyssiotis/  
OnCo record `costas-lyssiotis` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Costas Lyssiotis shows how pancreatic tumours feed off their surrounding cells and how to cut the supply.

## Summary

Costas A. Lyssiotis is Maisel Research Professor of Oncology at the University of Michigan Rogel Cancer Center, working on cancer metabolism in pancreatic cancer. He is known for showing how pancreatic tumours feed off their surrounding cells, describing the exchange of alanine between pancreatic stellate cells and cancer cells. His selected paper reports that pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. He now studies tumour-stroma metabolic crosstalk and metabolic dependencies that could be exploited with drugs.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Maisel Research Professor of Oncology
- Specialisms: Cancer metabolism; Pancreatic cancer; Tumour-stroma metabolic crosstalk

## Sources

- Michigan profile: https://www.rogelcancercenter.org/costas-lyssiotis-phd
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Lyssiotis%20CA%5BAuthor%5D

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- institutions: [University of Michigan Rogel Cancer Center](https://onco.cc/institutions/michigan-rogel/)

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