# CPEB3

Source: https://onco.cc/targets/cpeb3/  
OnCo record `cpeb3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.

## Summary

Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Basal Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cytoplasmic polyadenylation element binding protein 3; Cytoplasmic polyadenylation element-binding protein 3; KIAA0940
- Tags: cancer-genes-wave
- Symbol: CPEB3
- Class: oncogene
- Biology: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. Location: Cytoplasm; Nucleus; Synapse; Cell projection, dendrite (UniProt). Locus 10q23.32 (HGNC).
- Where found: Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:21746: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21746
- UniProt Q8NE35: https://www.uniprot.org/uniprotkb/Q8NE35/entry
- NCBI Gene 22849: https://www.ncbi.nlm.nih.gov/gene/22849
- Ensembl ENSG00000107864: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107864

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/)

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JSON: https://onco.cc/api/v1/entities/cpeb3.json