# CPSF6

Source: https://onco.cc/targets/cpsf6/  
OnCo record `cpsf6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CPSF6 (Cleavage and polyadenylation specificity factor subunit 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.

## Summary

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.94, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cleavage and polyadenylation specific factor 6; Cleavage and polyadenylation specificity factor subunit 6; HPBRII-4; HPBRII-7; CFIM68; CFIM72
- Tags: cancer-genes-wave
- Symbol: CPSF6
- Class: other
- Biology: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localised in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localised upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle; Cytoplasm (UniProt). Locus 12q15 (HGNC).
- Where found: Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13871: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13871
- UniProt Q16630: https://www.uniprot.org/uniprotkb/Q16630/entry
- NCBI Gene 11052: https://www.ncbi.nlm.nih.gov/gene/11052
- Ensembl ENSG00000111605: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111605

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)

---
JSON: https://onco.cc/api/v1/entities/cpsf6.json