# CPVL

Source: https://onco.cc/targets/cpvl/  
OnCo record `cpvl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.

## Summary

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.86, animal model 0.57, genetic association 0.75).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: carboxypeptidase vitellogenic like; Probable serine carboxypeptidase CPVL
- Tags: cancer-genes-wave
- Symbol: CPVL
- Class: enzyme
- Biology: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).
- Where found: Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898); Basal cell carcinoma: Open Targets association 0.55 with basal cell carcinoma (MONDO_0020804)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14399: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14399
- UniProt Q9H3G5: https://www.uniprot.org/uniprotkb/Q9H3G5/entry
- NCBI Gene 54504: https://www.ncbi.nlm.nih.gov/gene/54504
- Ensembl ENSG00000106066: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106066

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/cpvl.json