# CREB1

Source: https://onco.cc/targets/creb1/  
OnCo record `creb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CREB1 (Cyclic AMP-responsive element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Sarcomas, Skin cancer and 1 more.

## Summary

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronisation of circadian rhythmicity and the differentiation of adipose cells.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, animal model 0.57, genetic association 0.00, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cAMP responsive element binding protein 1; Cyclic AMP-responsive element-binding protein 1
- Tags: cancer-genes-wave
- Symbol: CREB1
- Class: transcription
- Biology: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronisation of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signalling. Location: Nucleus (UniProt). Locus 2q33.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254); Sarcomas: Open Targets association 0.52 with sarcoma (MONDO_0005089); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2345: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2345
- UniProt P16220: https://www.uniprot.org/uniprotkb/P16220/entry
- NCBI Gene 1385: https://www.ncbi.nlm.nih.gov/gene/1385
- Ensembl ENSG00000118260: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118260

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

---
JSON: https://onco.cc/api/v1/entities/creb1.json