# CREB3L2

Source: https://onco.cc/targets/creb3l2/  
OnCo record `creb3l2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer and Lung cancer.

## Summary

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, animal model 0.54, genetic association 0.00, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cAMP responsive element binding protein 3 like 2; Cyclic AMP-responsive element-binding protein 3-like protein 2; BBF2H7; TCAG_1951439
- Tags: cancer-genes-wave
- Symbol: CREB3L2
- Class: transcription
- Biology: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. Location: Endoplasmic reticulum membrane; Nucleus (UniProt). Locus 7q33 (HGNC).
- Where found: Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089); Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23720: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23720
- UniProt Q70SY1: https://www.uniprot.org/uniprotkb/Q70SY1/entry
- NCBI Gene 64764: https://www.ncbi.nlm.nih.gov/gene/64764
- Ensembl ENSG00000182158: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182158

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/creb3l2.json