# CRKL

Source: https://onco.cc/targets/crkl/  
OnCo record `crkl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.

## Summary

May mediate the transduction of intracellular signals.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Gefitinib and Dasatinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CRK like proto-oncogene, adaptor protein; Crk-like protein
- Tags: cancer-genes-wave
- Symbol: CRKL
- Class: other
- Biology: May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2363: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2363
- UniProt P46109: https://www.uniprot.org/uniprotkb/P46109/entry
- NCBI Gene 1399: https://www.ncbi.nlm.nih.gov/gene/1399
- Ensembl ENSG00000099942: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000099942

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- pathways: [Chronic myeloid leukaemia (KEGG map)](https://onco.cc/pathways/cml-signalling/)

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JSON: https://onco.cc/api/v1/entities/crkl.json