# CRTC1

Source: https://onco.cc/targets/crtc1/  
OnCo record `crtc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.

## Summary

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.82, animal model 0.26, genetic association 0.26, somatic mutation 0.84). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; KIAA0616; FLJ14027; TORC1; MECT1
- Tags: cancer-genes-wave
- Symbol: CRTC1
- Class: oncogene
- Biology: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.11 (HGNC).
- Where found: Salivary gland cancers: IntOGen driver in 1 cohort (ACYC); Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575); Oesophageal cancer: Open Targets association 0.51 with oesophageal cancer (MONDO_0007576); Mucoepidermoid carcinoma: Open Targets association 0.58 with mucoepidermoid carcinoma (MONDO_0003036)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16062: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16062
- UniProt Q6UUV9: https://www.uniprot.org/uniprotkb/Q6UUV9/entry
- NCBI Gene 23373: https://www.ncbi.nlm.nih.gov/gene/23373
- Ensembl ENSG00000105662: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105662

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Adenoid cystic carcinoma](https://onco.cc/cancers/adenoid-cystic-carcinoma/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Mucoepidermoid carcinoma](https://onco.cc/cancers/mucoepidermoid-carcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/), [Salivary gland cancers](https://onco.cc/cancers/salivary-gland/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/crtc1.json