# G-CSF receptor (CSF3R)

Source: https://onco.cc/targets/csf3r/  
OnCo record `csf3r` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The receptor that tells the bone marrow to make neutrophils. Filgrastim and pegfilgrastim stimulate it to shorten the dangerous low-neutrophil period after chemotherapy, cutting the risk of febrile neutropenia.

## Summary

The granulocyte colony-stimulating factor receptor on myeloid progenitors drives neutrophil production and release through JAK2 and STAT3 signalling. Recombinant G-CSF (filgrastim) and its long-acting pegylated form (pegfilgrastim) are given after myelosuppressive chemotherapy to shorten neutropenia and are recommended when the regimen carries a high risk of febrile neutropenia. They also mobilise stem cells before autologous transplantation. Activating CSF3R mutations define chronic neutrophilic leukaemia, which responds to the JAK inhibitor ruxolitinib.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Symbol: CSF3R
- Class: other
- Biology: Cytokine receptor on neutrophil progenitors signalling through JAK2 and STAT3; agonised by recombinant G-CSF.
- Where found: Supportive care after chemotherapy (all cancers); Chronic neutrophilic leukaemia (activating mutations)

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor_receptor
- UniProt Q99062: CSF3R: https://www.uniprot.org/uniprotkb/Q99062/entry

## Connected records

- targets: [GM-CSF receptor (CSF2RA)](https://onco.cc/targets/csf2ra/), [JAK2](https://onco.cc/targets/jak2/)
- drugs: [Eflapegrastim](https://onco.cc/drugs/eflapegrastim/), [Filgrastim (G-CSF)](https://onco.cc/drugs/filgrastim/), [Lenograstim](https://onco.cc/drugs/lenograstim/), [Pegfilgrastim](https://onco.cc/drugs/pegfilgrastim/)
- terms: [Febrile neutropenia](https://onco.cc/terms/febrile-neutropenia/), [Neutropenia](https://onco.cc/terms/neutropenia/)

---
JSON: https://onco.cc/api/v1/entities/csf3r.json