# CSNK1A1

Source: https://onco.cc/targets/csnk1a1/  
OnCo record `csnk1a1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.89, genetic association 0.17, somatic mutation 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: casein kinase 1 alpha 1; Casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha
- Tags: cancer-genes-wave
- Symbol: CSNK1A1
- Class: kinase
- Biology: Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus speckle (UniProt). Locus 5q32 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2451: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2451
- UniProt P48729: https://www.uniprot.org/uniprotkb/P48729/entry
- NCBI Gene 1452: https://www.ncbi.nlm.nih.gov/gene/1452
- Ensembl ENSG00000113712: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113712

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/csnk1a1.json