# CSNK1E

Source: https://onco.cc/targets/csnk1e/  
OnCo record `csnk1e` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma.

## Summary

Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: casein kinase 1 epsilon; Casein kinase I isoform epsilon; HCKIE; CKIepsilon
- Tags: cancer-genes-wave
- Symbol: CSNK1E
- Class: kinase
- Biology: Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908); Follicular lymphoma: Open Targets association 0.52 with follicular lymphoma (MONDO_0018906)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2453: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2453
- UniProt P49674: https://www.uniprot.org/uniprotkb/P49674/entry
- NCBI Gene 1454: https://www.ncbi.nlm.nih.gov/gene/1454
- Ensembl ENSG00000213923: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213923

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Follicular lymphoma](https://onco.cc/cancers/follicular-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/csnk1e.json