# CTPH-03

Source: https://onco.cc/drugs/ctph-03/  
OnCo record `ctph-03` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CTPH-03 is an experimental drug designed to carry chemotherapy to cancer cells. Its published evidence is from laboratory and animal studies.

## Summary

AACR 2026 abstract 4438 describes CTPH-03 using an MMAE-based dual-payload format. Evidence comprises cell assays, cell-derived xenografts, rodent and monkey pharmacokinetics, and preliminary animal toxicity. The abstract describes patient-derived xenograft and IND-enabling studies as preparation. Neither the second payload identity nor human efficacy or safety can be inferred from these findings.

## Fields

- Kind: Treatment
- Status: preclinical
- Last checked: 2026-10-06
- Tags: evidence:preclinical
- Modality: ADC
- Mechanism: TROP2-directed ADC carrying an MMAE-based dual-payload combination; the other payload is not identified by the public abstract.
- Payload: MMAE-based dual payload; second payload not disclosed in the cited abstract

## Sources

- Publisher abstract: https://doi.org/10.1158/1538-7445.am2026-4438

## Connected records

- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/), [Dual-payload ADC](https://onco.cc/technologies/dual-payload-adc/)
- targets: [TROP2](https://onco.cc/targets/trop2/)

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JSON: https://onco.cc/api/v1/entities/ctph-03.json