# CTR9

Source: https://onco.cc/targets/ctr9/  
OnCo record `ctr9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CTR9 (RNA polymerase-associated protein CTR9 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.

## Summary

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.57, genetic literature 0.74).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: CTR9 component of Paf1/RNA polymerase II complex; RNA polymerase-associated protein CTR9 homolog; KIAA0155; p150TSP; SH2BP1
- Tags: cancer-genes-wave
- Symbol: CTR9
- Class: transcription
- Biology: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in haematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. Location: Nucleus speckle (UniProt). Locus 11p15.4 (HGNC).
- Where found: Wilms tumour: Open Targets association 0.58 with Wilms tumour (MONDO_0006058)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16850: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16850
- UniProt Q6PD62: https://www.uniprot.org/uniprotkb/Q6PD62/entry
- NCBI Gene 9646: https://www.ncbi.nlm.nih.gov/gene/9646
- Ensembl ENSG00000198730: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198730

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Wilms tumour (nephroblastoma)](https://onco.cc/cancers/wilms-tumor/)

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JSON: https://onco.cc/api/v1/entities/ctr9.json