# CTSH

Source: https://onco.cc/targets/ctsh/  
OnCo record `ctsh` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Important for the overall degradation of proteins in lysosomes.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.93, animal model 0.81, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cathepsin H; Pro-cathepsin H; ACC-4; ACC-5; ACC4; ACC5
- Tags: cancer-genes-wave
- Symbol: CTSH
- Class: enzyme
- Biology: Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt). Locus 15q25.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2535: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2535
- UniProt P09668: https://www.uniprot.org/uniprotkb/P09668/entry
- NCBI Gene 1512: https://www.ncbi.nlm.nih.gov/gene/1512
- Ensembl ENSG00000103811: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103811

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ctsh.json