# CUL7

Source: https://onco.cc/targets/cul7/  
OnCo record `cul7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CUL7 (Cullin-7) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.

## Summary

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cullin 7; Cullin-7; dJ20C7.5; KIAA0076
- Tags: cancer-genes-wave
- Symbol: CUL7
- Class: other
- Biology: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53. However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, perinuclear region; Golgi apparatus (UniProt). Locus 6p21.1 (HGNC).
- Where found: Glioma & glioblastoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Brain Glioma.

## Sources

- HGNC HGNC:21024: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21024
- UniProt Q14999: https://www.uniprot.org/uniprotkb/Q14999/entry
- NCBI Gene 9820: https://www.ncbi.nlm.nih.gov/gene/9820
- Ensembl ENSG00000044090: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000044090

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

---
JSON: https://onco.cc/api/v1/entities/cul7.json