# Cyclizine

Source: https://onco.cc/drugs/cyclizine/  
OnCo record `cyclizine` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Cyclizine is an anti-sickness tablet or injection widely used in the UK, including for sickness caused by opioid painkillers and by radiotherapy.

## Summary

The UK SmPCs list prevention and treatment of nausea and vomiting from motion sickness, from narcotic analgesics and general anaesthetics after surgery, and "vomiting associated with radiotherapy especially for breast cancer since Cyclizine does not elevate prolactin levels". The Scottish Palliative Care Guidelines advise against prescribing a prokinetic such as metoclopramide together with an anticholinergic such as cyclizine, because the anticholinergic diminishes the prokinetic effect. It is not marketed as a prescription medicine in the US.

## Fields

- Kind: Treatment
- Status: approved
- Last checked: 2026-11-11
- Tags: supportive; generic; supportive-care-gaps-2026-11
- Brand: Valoid
- Modality: Antihistamine antiemetic (H1 receptor antagonist)
- Mechanism: A histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties (UK SmPC 5.1).
- Approvals: UK 2001: Prevention and treatment of nausea and vomiting: motion sickness, narcotic analgesics and general anaesthetics after surgery, and vomiting with radiotherapy, especially for breast cancer

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Cyclizine
- UK SmPC (emc): cyclizine 50 mg tablets: https://www.medicines.org.uk/emc/product/4318/smpc
- UK SmPC (emc): cyclizine 50 mg/ml injection: https://www.medicines.org.uk/emc/product/100940/smpc
- Scottish Palliative Care Guidelines: nausea and vomiting: https://www.palliativecareguidelines.scot.nhs.uk/scottish-palliative-care-guidelines/symptoms/non-pain-symptoms/nausea-and-vomiting/

## Connected records

- drugs: [Metoclopramide](https://onco.cc/drugs/metoclopramide/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- technologies: [Antiemetics for chemotherapy-induced nausea and vomiting](https://onco.cc/technologies/antiemetic-therapy/)

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JSON: https://onco.cc/api/v1/entities/cyclizine.json