# CYP11B1

Source: https://onco.cc/targets/cyp11b1/  
OnCo record `cyp11b1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.

## Summary

A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.27, animal model 0.54, genetic association 0.00, clinical 0.83).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cytochrome P450 family 11 subfamily B member 1; Cytochrome P450 11B1, mitochondrial; P450C11; CPN1; CYP11B
- Tags: cancer-genes-wave
- Symbol: CYP11B1
- Class: enzyme
- Biology: A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyses the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Location: Mitochondrion inner membrane (UniProt). Locus 8q24.3 (HGNC).
- Where found: Renal cell carcinoma: Open Targets association 0.52 with renal cell carcinoma (MONDO_0005086)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2591: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2591
- UniProt P15538: https://www.uniprot.org/uniprotkb/P15538/entry
- NCBI Gene 1584: https://www.ncbi.nlm.nih.gov/gene/1584
- Ensembl ENSG00000160882: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160882

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/cyp11b1.json