# CYP2C8

Source: https://onco.cc/targets/cyp2c8/  
OnCo record `cyp2c8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.

## Summary

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond.

IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Pleural Mesothelioma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cytochrome P450 family 2 subfamily C member 8; Cytochrome P450 2C8; CPC8
- Tags: cancer-genes-wave
- Symbol: CYP2C8
- Class: oncogene
- Biology: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward oestrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 10q23.33 (HGNC).
- Where found: Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Melanoma: IntOGen driver in 1 cohort (MEL); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2622: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2622
- UniProt P10632: https://www.uniprot.org/uniprotkb/P10632/entry
- NCBI Gene 1558: https://www.ncbi.nlm.nih.gov/gene/1558
- Ensembl ENSG00000138115: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138115

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/)

---
JSON: https://onco.cc/api/v1/entities/cyp2c8.json