# CYP2D6

Source: https://onco.cc/targets/cyp2d6/  
OnCo record `cyp2d6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA).

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene); Cytochrome P450 2D6; CPD6; P450-DB1; CYP2D; P450C2D; CYP2DL1; CYP2D7P2; CYP2D7BP; CYP2D8P2; CYP2D7AP
- Tags: cancer-genes-wave
- Symbol: CYP2D6
- Class: enzyme
- Biology: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolises endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signalling. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 22q13.2 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2625: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2625
- UniProt P10635: https://www.uniprot.org/uniprotkb/P10635/entry
- NCBI Gene 1565: https://www.ncbi.nlm.nih.gov/gene/1565
- Ensembl ENSG00000100197: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100197

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- trials: [Efficacy of Tamoxifen Versus Toremifene in CYP2D6 IM/PM of Premenopausal Patients With ER-positive Early Breast Cancer](https://onco.cc/trials/nct03351062/)

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