# Darren R. Hargrave

Source: https://onco.cc/people/darren-hargrave/  
OnCo record `darren-hargrave` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

London paediatric neuro-oncologist who led the trial showing that dabrafenib and trametinib work in children with BRAF V600-mutant high-grade glioma.

## Summary

Darren Hargrave is a paediatric neuro-oncologist at Great Ormond Street Hospital and a leader of European paediatric drug-development consortia. He was first author of the 2023 Journal of Clinical Oncology report of the phase 2 trial in which dabrafenib plus trametinib produced responses in relapsed or refractory BRAF V600-mutant paediatric high-grade glioma, and a senior investigator on the trial that established the same combination for paediatric low-grade glioma.

## Fields

- Kind: Person
- Last checked: 2026-09-18
- Tags: paediatric; brain; targeted-therapy; trialist
- Role: Paediatric neuro-oncologist, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health
- Specialisms: Paediatric glioma; BRAF-directed therapy; Paediatric drug development

## Connected records

- cancers: [Childhood cancers (all types)](https://onco.cc/cancers/childhood-cancers/), [Paediatric high-grade glioma (excluding diffuse midline glioma)](https://onco.cc/cancers/paediatric-high-grade-glioma/)
- institutions: [Great Ormond Street Hospital for Children](https://onco.cc/institutions/great-ormond-street/)
- key papers: [Dabrafenib plus trametinib in relapsed or refractory BRAF V600-mutant paediatric high-grade glioma](https://onco.cc/key-papers/paper-hargrave-dabrafenib-trametinib-paediatric-hgg-jco-2023/)

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