# David Sebag-Montefiore

Source: https://onco.cc/people/david-sebag-montefiore/  
OnCo record `david-sebag-montefiore` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Leeds clinical oncologist who led CR07, the trial that made short-course radiotherapy before surgery the standard for rectal cancer, and who now works on preserving the rectum instead of removing it.

## Summary

David Sebag-Montefiore is an academic clinical oncologist at the University of Leeds and an honorary clinical oncologist at Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust. He leads the Leeds Radiotherapy Research Group and is a clinical director of the Leeds Clinical Trials Research Unit; he was awarded the Audrey and Stanley Burton Chair of Clinical Oncology in 2012. He was first author of MRC CR07, which showed that short-course preoperative radiotherapy cut local recurrence by 61 percent against surgery with selective postoperative chemoradiotherapy, and is second author of the STAR-TREC 12-month results, the first randomised comparison of two radiotherapy schedules for organ preservation in rectal cancer.

## Fields

- Kind: Person
- Last checked: 2026-09-24
- Tags: colorectal; trialist; uk; radiotherapy
- Role: Professor of Clinical Oncology (Audrey and Stanley Burton Chair), University of Leeds; Clinical Director, Leeds Clinical Trials Research Unit
- Specialisms: Rectal cancer radiotherapy; Organ preservation; Randomised radiotherapy trials

## Sources

- University of Leeds staff page: https://medicinehealth.leeds.ac.uk/medicine/staff/745/professor-david-sebag-montefiore

## Connected records

- people: [Dion Morton](https://onco.cc/people/dion-morton/), [Matt Seymour](https://onco.cc/people/matt-seymour/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- fronts: [Radiation Therapy](https://onco.cc/fronts/radiation/)
- institutions: [Leeds Cancer Centre, St James's University Hospital](https://onco.cc/institutions/leeds-cancer-centre/)
- terms: [Radiotherapy](https://onco.cc/terms/radiotherapy/)
- trials: [MRC CR07](https://onco.cc/trials/cr07/), [STAR-TREC](https://onco.cc/trials/star-trec/)

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JSON: https://onco.cc/api/v1/entities/david-sebag-montefiore.json