# DAXX

Source: https://onco.cc/targets/daxx/  
OnCo record `daxx` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DAXX (Death domain-associated protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Adrenocortical carcinoma, Pancreatic ductal adenocarcinoma and 2 more.

## Summary

Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.

Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.61, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Adrenocortical Carcinoma, Pancreas, Pancreatic Neuroendocrine Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: death domain associated protein; Death domain-associated protein 6; DAP6
- Tags: cancer-genes-wave
- Symbol: DAXX
- Class: tumor-suppressor
- Biology: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Location: Cytoplasm; Nucleus, nucleoplasm; Nucleus, PML body; Nucleus, nucleolus (UniProt). Locus 6p21.32 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.61 with neuroendocrine neoplasm (MONDO_0019496); IntOGen driver in 1 cohort (PANET); Adrenocortical carcinoma: IntOGen driver in 1 cohort (ACC); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PANCREAS); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2681: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2681
- UniProt Q9UER7: https://www.uniprot.org/uniprotkb/Q9UER7/entry
- NCBI Gene 1616: https://www.ncbi.nlm.nih.gov/gene/1616
- Ensembl ENSG00000204209: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204209

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Adrenocortical carcinoma](https://onco.cc/cancers/adrenocortical/), [Melanoma](https://onco.cc/cancers/melanoma/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)
- pathways: [Telomere maintenance & replicative immortality](https://onco.cc/pathways/telomere-maintenance/)

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JSON: https://onco.cc/api/v1/entities/daxx.json