# DCAF12L2

Source: https://onco.cc/targets/dcaf12l2/  
OnCo record `dcaf12l2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.

## Summary

UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2".

IntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Colon Adenocarcinoma, Glioblastoma Multiforme, Lung Adenocarcinoma, Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DDB1 and CUL4 associated factor 12 like 2; DDB1- and CUL4-associated factor 12-like protein 2; WDR40C
- Tags: cancer-genes-wave
- Symbol: DCAF12L2
- Class: oncogene
- Biology: UniProt has no function text for Q5VW00; HGNC names it "DDB1 and CUL4 associated factor 12 like 2". Locus Xq25 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COAD); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:32950: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32950
- UniProt Q5VW00: https://www.uniprot.org/uniprotkb/Q5VW00/entry
- NCBI Gene 340578: https://www.ncbi.nlm.nih.gov/gene/340578
- Ensembl ENSG00000198354: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198354

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Prostate cancer](https://onco.cc/cancers/prostate/)

---
JSON: https://onco.cc/api/v1/entities/dcaf12l2.json