# DCLK1

Source: https://onco.cc/targets/dclk1/  
OnCo record `dclk1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.

## Summary

UniProt describes DCLK1 as a probable kinase of neuronal migration expressed in the adult brain and, at lower levels, in the gut and other organs. In cancer research it is followed as a marker of tuft-like intestinal stem cells implicated in colorectal and pancreatic tumour initiation, and its transcript and protein levels track each other closely in proteogenomic data.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: doublecortin like kinase 1; DCAMKL1; DCLK
- Tags: cansim-terms
- Symbol: DCLK1
- Class: kinase
- Biology: Probable kinase in a calcium-signalling pathway controlling neuronal migration; in adults expressed in brain and detectable in heart, liver, spleen, prostate, ovary, small intestine and colon (UniProt O15075).
- Where found: Locus 13q13.3 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:2700: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2700
- UniProt O15075: https://www.uniprot.org/uniprotkb/O15075/entry

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/), [mRNA to protein concordance](https://onco.cc/terms/mrna-protein-concordance/)

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JSON: https://onco.cc/api/v1/entities/dclk1.json