# DDIT3

Source: https://onco.cc/targets/ddit3/  
OnCo record `ddit3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.

## Summary

Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.97, genetic literature 0.30).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DNA damage inducible transcript 3; DDIT3 upstream open reading frame protein; CHOP10; GADD153
- Tags: cancer-genes-wave
- Symbol: DDIT3
- Class: other
- Biology: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.3 (HGNC).
- Where found: Sarcomas: Open Targets association 0.63 with sarcoma (MONDO_0005089); Liposarcoma: Open Targets association 0.60 with liposarcoma (MONDO_0005060)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2726: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2726
- UniProt P0DPQ6: https://www.uniprot.org/uniprotkb/P0DPQ6/entry
- NCBI Gene 1649: https://www.ncbi.nlm.nih.gov/gene/1649
- Ensembl ENSG00000175197: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175197

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Liposarcoma](https://onco.cc/cancers/liposarcoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/ddit3.json