# DDR2 receptor kinase

Source: https://onco.cc/targets/ddr2/  
OnCo record `ddr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDR2 is a receptor that senses collagen; mutations in it occur in a small share of squamous lung cancers, and dasatinib inhibits it.

## Summary

Discoidin domain receptor 2 is a receptor tyrosine kinase activated by fibrillar collagen rather than by a growth factor. DDR2 mutations were found in around 4 percent of squamous non-small cell lung cancers, and the leukaemia drug dasatinib inhibits DDR2 strongly, which prompted trials in DDR2-mutant lung cancer; responses were seen but the approach did not reach approval.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Symbol: DDR2
- Class: kinase
- Biology: Collagen binding through the discoidin domain triggers slow, sustained kinase activation, regulating cell adhesion, migration and matrix remodelling.
- Where found: Squamous non-small cell lung cancer (a small mutated subset); Fibroblasts and stromal cells

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Discoidin_domain-containing_receptor_2
- UniProt Q16832: DDR2: https://www.uniprot.org/uniprotkb/Q16832/entry
- HGNC:2731 DDR2: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2731
- ChEMBL target CHEMBL5122: https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5122

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Dasatinib](https://onco.cc/drugs/dasatinib/)

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JSON: https://onco.cc/api/v1/entities/ddr2.json