# DDX10

Source: https://onco.cc/targets/ddx10/  
OnCo record `ddx10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.

## Summary

Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.87, animal model 0.31, genetic association 0.04, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 10; Probable ATP-dependent RNA helicase DDX10; HRH-J8; Dbp4
- Tags: cancer-genes-wave
- Symbol: DDX10
- Class: enzyme
- Biology: Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 11q22.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2735: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2735
- UniProt Q13206: https://www.uniprot.org/uniprotkb/Q13206/entry
- NCBI Gene 1662: https://www.ncbi.nlm.nih.gov/gene/1662
- Ensembl ENSG00000178105: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178105

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ddx10.json