# DDX3X

Source: https://onco.cc/targets/ddx3x/  
OnCo record `ddx3x` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX3X (ATP-dependent RNA helicase DDX3X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.

## Summary

Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.28, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 23 cohorts (14 activating, 9 loss-of-function), covering Burkitt Lymphoma, Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Head and Neck Squamous Cell Carcinoma, Lymphoid Neoplasm and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 3 X-linked; ATP-dependent RNA helicase DDX3X; HLP2; DDX14; CAP-Rf; DDX3
- Tags: cancer-genes-wave
- Symbol: DDX3X
- Class: transcription
- Biology: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Location: Cell membrane; Nucleus; Cytoplasm; Cytoplasm, Stress granule (UniProt). Locus Xp11.4 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.73 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (LNM, MLYM, NHL); Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059); Breast cancer: IntOGen driver in 2 cohorts (BRCA); Mesothelioma: IntOGen driver in 2 cohorts (PLMESO); Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 14 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2745: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2745
- UniProt O00571: https://www.uniprot.org/uniprotkb/O00571/entry
- NCBI Gene 1654: https://www.ncbi.nlm.nih.gov/gene/1654
- Ensembl ENSG00000215301: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000215301

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ddx3x.json