# DDX41

Source: https://onco.cc/targets/ddx41/  
OnCo record `ddx41` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX41 (Probable ATP-dependent RNA helicase DDX41) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Myeloproliferative neoplasms, Myelodysplastic syndromes / neoplasms and 1 more.

## Summary

Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and haematopoietic homeostasis. Recognises foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses.

CIViC holds 11 clinical evidence items and 1 assertion across 4 variants. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.94, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 41; Probable ATP-dependent RNA helicase DDX41; MGC8828
- Tags: cancer-genes-wave
- Symbol: DDX41
- Class: enzyme
- Biology: Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and haematopoietic homeostasis. Recognises foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses. Location: Nucleus; Cytoplasm (UniProt). Locus 5q35.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.77 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.77 with myeloproliferative neoplasm (MONDO_0020076); Myelodysplastic syndromes / neoplasms: Open Targets association 0.69 with myelodysplastic syndrome (MONDO_0018881); CIViC evidence names this disease; Acute myeloid leukaemia: Open Targets association 0.72 with acute myeloid leukaemia (MONDO_0018874); CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 11 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Myeloid Neoplasm; Haematologic Cancer.

## Sources

- HGNC HGNC:18674: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18674
- UniProt Q9UJV9: https://www.uniprot.org/uniprotkb/Q9UJV9/entry
- NCBI Gene 51428: https://www.ncbi.nlm.nih.gov/gene/51428
- Ensembl ENSG00000183258: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183258

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/ddx41.json