# DDX43

Source: https://onco.cc/targets/ddx43/  
OnCo record `ddx43` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX43 (Probable ATP-dependent RNA helicase DDX43) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Uveal melanoma.

## Summary

UniProt has no function text for Q9NXZ2; HGNC names it "DEAD-box helicase 43".

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib, Mirdametinib and Selumetinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 43; Probable ATP-dependent RNA helicase DDX43; DKFZp434H2114; CT13
- Tags: cancer-genes-wave
- Symbol: DDX43
- Class: enzyme
- Biology: UniProt has no function text for Q9NXZ2; HGNC names it "DEAD-box helicase 43". Locus 6q13 (HGNC).
- Where found: Uveal melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18677: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18677
- UniProt Q9NXZ2: https://www.uniprot.org/uniprotkb/Q9NXZ2/entry
- NCBI Gene 55510: https://www.ncbi.nlm.nih.gov/gene/55510
- Ensembl ENSG00000080007: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000080007

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Uveal melanoma](https://onco.cc/cancers/uveal-melanoma/)

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JSON: https://onco.cc/api/v1/entities/ddx43.json